Tiamulin hydrogen fumarate
Tiamulin hydrogen fumarate
$96.00 - 25 mg
$336.00 - 100 mg
All prices in Australian dollars
- Code
- BIA-T1322
- CAS #
- 55297-96-6
- Molecular Formula
- C32H51NO8S
- Molecular Weight
- 609.8
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
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Application Notes
Tiamulin is a semi–synthetic analogue of pleuromutilin in which the hydroxyacetyl side chain is replaced with a larger diethylaminoethylthioacetyl moiety, providing greater hydrophobicity. The hemi-fumarate provides a stable salt with improved water solubility. Tiamulin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action of inhibiting protein synthesis by binding to domain V of 23S rRNA.
References
- New pleuromutilin derivative with enhanced antimicrobial activity. I. Synthesis. Egger H. & Reinshagen H. J. Antibiot. 1976, 29, 915.
- Pleuromutilin antibiotics. Hunt E. Drugs Future 2000, 25, 1163.