Roseoflavin

Roseoflavin

$132.00 - 1 mg

$462.00 - 5 mg

All prices in Australian dollars

Code
BIA-R1535
Synonyms
8-Dimethylaminoriboflavin, Roseoflavine
CAS #
51093-55-1
Molecular Formula
C18H23N5O6
Molecular Weight
405.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Roseoflavin is an antibacterial pigment isolated from Streptomyces davawensis as an anti-metabolite of riboflavin. Roseoflavin is used as a substrate to mimic riboflavin in flavin biosynthesis, but leading to the formation of inactive flavin co-factors. More recently, roseoflavin has been shown to be an important regulator of bacterial gene expression by binding to untranslated regions of RNA, so-called ribo-switching sites.

References

  • Roseoflavin, a new antimicrobial pigment from Streptomyces. Otani S. et al., J. Antibiot. 1994, 27, 86.
  • The bifunctional flavokinase/flavin adenine dinucleotide synthetase from Streptomyces davawensis produces inactive flavin cofactors and is not involved in resistance to the antibiotic roseoflavin. Grill S. et al., J. Bacteriol. 2008, 190, 1546.
  • Riboswitches as antibacterial drug targets Blount K.F. & Breaker R.R.: Nat. Biotechnol. 2006, 24, 1558.

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