Anguinomycin A

Anguinomycin A

$368.00 - 0.10 mg

$1,288.00 - 0.50 mg

All prices in Australian dollars

Synonyms
5-Demethylleptomycin A, KR 2827A
CAS #
111278-01-4
Molecular Formula
C31H44O6
Molecular Weight
512.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.
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Application Notes

Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumor activity in vivo against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of leptomycin B, an inhibitor of nuclear export of proteins.

References

  • Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. Hayakawa Y., et al., J. Antibiot., 1995, 48, 954.
  • New antitumor antibiotics, anguinomycins A and B. Hayakawa Y., et al., J. Antibiot., 1987, 40, 1349.

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