Phomopsin D is the dihydro derivative of phomopsin A, an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an ‘ansa’ macrocycle. Phomopsin D, like other phomopsins, is a potent mycotoxin found in infected lupins. Phomopsin D binds selectively to dimeric tubulin at a site overlapping that of vinblastine and maytansine, inhibiting the formation of the microtubule spindle to block cell division.
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