Phomopsin D

Phomopsin D

$215.00 - 0.50 mg

$755.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-P2987
CAS #
175617-09-1
Molecular Formula
C36H47ClN6O12
Molecular Weight
791.25
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Phomopsin D is the dihydro derivative of phomopsin A, an acidic 13-membered cyclic hexapeptide-like metabolite with three unusual amino acids linked in an ‘ansa’ macrocycle. Phomopsin D, like other phomopsins, is a potent mycotoxin found in infected lupins. Phomopsin D binds selectively to dimeric tubulin at a site overlapping that of vinblastine and maytansine, inhibiting the formation of the microtubule spindle to block cell division.

References

  • Identification of novel phomopsins in lupine seed extracts. Cockrum P.A. et al. Proceedings of the 4th International Symposium on Poisonous Plants, 1994, 232.
  • Structure elucidation and absolute configuration of phomopsin A, a hexapeptide mycotoxin produced by phomopsis leptostromiformis. Culvenor C.C.J. et al. Tetrahedron 1989, 45, 2351.
  • Interaction of phomopsin A and related compounds with purified sheep brain tubulin. E. Lacey et al. Biochem Pharmacol. 1987, 36, 2133.

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