Heveadride

Heveadride

$260.00 - 1 mg

$910.00 - 5 mg

All prices in Australian dollars

Code
BIA-H2985
CAS #
39595-41-0
Molecular Formula
C18H20O6
Molecular Weight
332.35
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Heveadride is a nonadride lactone related to byssochlamic acid, produced by several fungal species, including Helminthosporium heveae and Bipolaris heveae. Heveadride is active against various filamentous fungi and some human pathogenic yeasts such as Trichosporon sp.. Heaveadride induces dose-dependent down-regulation of TNFα-induced NF-κB activity in human chronic myeloid leukemia cells with IC50s of 82 ± 11 μM. Heveadride has not been extensively studied.

References

  • Fungal products. Part. IV. The structure of heveadride, a new nonadride from Helminthosporium heveae. Crane R.I. et al. J. Chem. Soc., Perkin Trans. 1, 1973, 194.
  • A new nonadride derivative, dihydroepiheveadride, as characteristic antifungal agent against filamentous fungi, isolated from unidentified fungus IFM 52672. Hosoe T. et al. J Antibiot. 2004, 57, 573.
  • Epipolythiodiketopiperazines from the marine derived fungus Dichotomomyces cejpii with NF-κb inhibitory potential. Orlikova B. et al. Marine Drugs 2015, 13, 4949.

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