Oxanthromicin A, spiro
Oxanthromicin A, spiro
$180.00 - 0.10 mg
$630.00 - 0.50 mg
All prices in Australian dollars
- Code
- BIA-O2289
- CAS #
- 1616622-10-6
- Molecular Formula
- C36H26O10
- Molecular Weight
- 618.6
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in methanol or DMSO
Download Data Sheets
Application Notes
spiro-Oxanthromicin was first isolated from a soil-derived Streptomyces sp. by Capon and co-workers in 2014. spiro-Oxanthromicin inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells (IC50 27 µM) and is highly synergistic with its co-metabolites including (±)-oxanthromicin in this assay. spiro-Oxanthromicin inhibits Bacillus cereus (MIC 12.5 µg/mL) but was inactive against HSV-1, Mycobacterium tuberculosis H37Ra and phytopathogenic fungi. spiro-Oxanthromicin shows minimal cytotoxicity.
References
- Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Salim A. et al. Org Biomol Chem. 2014, 12, 4872.
- Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066. Bunbamrunga N. et al. Phytochem Lett. 2018, 25, 109.
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