Oxanthromicin A, spiro

Oxanthromicin A, spiro

$158.00 - 0.10 mg

$553.00 - 0.50 mg

All prices in Australian dollars

CAS #
1616622-10-6
Molecular Formula
C36H26O10
Molecular Weight
618.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

hemi-Oxanthromicin was first isolated from a soil-derived Streptomyces sp. by Capon and co-workers in 2014. spiro-Oxanthromicin inhibits mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells (IC50 27 µM) and is highly synergistic with its co-metabolites including (±)-oxanthromicin in this assay. spiro-Oxanthromicin inhibits Bacillus cereus (MIC 12.5 µg/mL) but was inactive against HSV-1, Mycobacterium tuberculosis H37Ra and phytopathogenic fungi. spiro-Oxanthromicin shows minimal cytotoxicity.

References

  • Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Salim A. et al. Org Biomol Chem 2014, 12, 4872.
  • Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066. Bunbamrunga N. et al. Phytochem Lett 2018, 25, 109. 

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