Anisomycin

Anisomycin

$133.00 - 25 mg

$466.00 - 100 mg

All prices in Australian dollars

Synonyms
Flagecidin, SA 3097C1, PA 106, Anhydroscopin A, NSC 76712
CAS #
22862-76-6
Molecular Formula
C14H19NO4
Molecular Weight
265.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

Anisomycin is a phenylmethylenepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin is an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. Anisomycin also induces apoptosis and is a selective signalling agonist, activates mitogen-activated protein (MAP) kinases and is immunomodulatory via its action on T cells.

References

  • Anisomycin, a new antiprotozoa antibiotic. Sobin B.A. & Tanner F.W. Jr., J. Am. Chem. Soc. 1954, 76, 4053
  • Selective inhibition of caspases during apoptotic induction in HL-60 cells. Effects of a tetrapeptide inhibitor. Polverino A.J. & Patterson S.D., J. Biol. Chem. 1997, 272, 7013.
  • Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38 (MAP kinase) activation and protein synthesis inhibition in mammalian cells. Barros L.F. et al., J. Physiol. 1997, 504, 517.

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