Doxorubicin
Doxorubicin
$525.00 - 5 mg
$150.00 - 1 mg
All prices in Australian dollars
- Code
- BIA-D1229
- Synonyms
- Adriamycin, 14-Hydroxydaunomycin, FI 106, K 1039, KW 125, NSC 123127
- CAS #
- 23214-92-8
- Molecular Formula
- C27H29NO11
- Molecular Weight
- 543.5
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Application Notes
Doxorubicin (adriamycin) is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumor agent for the treatment of a wide range of cancers. Doxorubicin also exhibits anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis.
References
- Adriamycin (14-hydroxydaunomycin), a novel antitumor antibiotic. Arcamone F. et al., Tet. Letters 1969, 13, 1007.
- Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Fornari F.L. et al., Mol. Pharmacology 1994, 45, 649.
- Effect of Adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Momarier R. et al., Cancer Research 1976, 36, 2891.