Nogalamycin

Nogalamycin

$220.00 - 5 mg

$770.00 - 25 mg

All prices in Australian dollars

Code
BIA-N1575
Synonyms
U 15167, Antibiotic U 15167
CAS #
1404-15-5
Molecular Formula
C39H49NO16
Molecular Weight
787.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.

References

  • Antibiotic nogalamycin and method of producing. Bhuyan B.K. et al., US Patent 3,183,157 1965.
  • Fermentation, taxonomic and biological studies of nogalamycin. Bhuyan B.K. et al., Antimicrob. Agents Chemother. 1965, 5, 836.
  • Structure of nogalamycin. Wiley P.F. J. Am. Chem. Soc. 1977, 99, 542.

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