Actinomycin D

Actinomycin D

$133.00 - 25 mg

$466.00 - 100 mg

All prices in Australian dollars

Synonyms
Dactinomycin, Actinomycin IV, Actinomycin Au3, Actinomycin B1, Actinomycin BiV, Actinomycin C1, Actinomycin DiV, Actinomycin Fo, Actinomycin I1, Actinomycin S2, Actinomycin X1, Auranthin A3, Auranthin C, NSC 3053, Chuoungwamycin B
CAS #
50-76-0
Molecular Formula
C62H86N12O16
Molecular Weight
1255.4
Purity
>99% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumor activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumor cell death has been demonstrated to occur by apoptosis.

References

  • Actinomycin. Part V. The structure of actinomycin D. Bullock E. J. Chem. Soc. 1957, 3280.
  • Apoptosis induced by actinomycin D, camptothecin or aphidicolin can occur in all phases of the cell cycle. Glynn J.M. et al., ; Biochem. Soc. Trans. 1992, 20, 84S.
  • Influence of DNA base sequence on the binding energetics of actinomycin D. Bailey S. A. et al., Biochemistry 1993, 32, 5881.

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