Actinomycin D

Actinomycin D

$133.00 - 25 mg

$466.00 - 100 mg

All prices in Australian dollars

Code
BIA-A1185
Synonyms
Dactinomycin, Actinomycin IV, Actinomycin Au3, Actinomycin B1, Actinomycin BiV, Actinomycin C1, Actinomycin DiV, Actinomycin Fo, Actinomycin I1, Actinomycin S2, Actinomycin X1, Auranthin A3, Auranthin C, NSC 3053, Chuoungwamycin B
CAS #
50-76-0
Molecular Formula
C62H86N12O16
Molecular Weight
1255.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

Actinomycin D is the most studied member of a family of unique bicyclic depsipeptides produced by several Streptomyces species. The depsipeptides are linked by a heterocyclic benzoxazone "anchor" that gives the metabolites a highly distinctive red/orange colour. Actinomycin D exhibits potent antibiotic and antitumor activity via DNA intercalation leading to the inhibition of nucleic acid synthesis. Tumor cell death has been demonstrated to occur by apoptosis.

References

  • Actinomycin. Part V. The structure of actinomycin D. Bullock E. J. Chem. Soc. 1957, 3280.
  • Apoptosis induced by actinomycin D, camptothecin or aphidicolin can occur in all phases of the cell cycle. Glynn J.M. et al., ; Biochem. Soc. Trans. 1992, 20, 84S.
  • Influence of DNA base sequence on the binding energetics of actinomycin D. Bailey S. A. et al., Biochemistry 1993, 32, 5881.

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