Nodulisporic acid A

Nodulisporic acid A

$235.00 - 1 mg

$823.00 - 5 mg

All prices in Australian dollars

Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Nodulisporic acid is an indole terpene produced by Nodulisporium sp. first reported by researchers at Merck in 1997. Nodulisporic acid A is a more potent insecticide than paraherquamide, exhibiting an LC50 of 0.5 ppm against A. aegypti and 0.3 ppm against L. seracata. Like ivermectin, nodulisporic acid A targets glutamate-gated chloride channels of the filarial nematode, Brugia malayi. Structure-activity relationship studies indicate that modifications to the left-hand side of the molecule result in loss of activity against fleas, whereas modifications to the C8 chain resulted in similar or superior insecticidal activity.


  • Nodulisporic acid A, a novel and potent insecticide from a Nodulisporium Sp. Isolation, structure determination, and chemical transformations. Ondeyka J.G. et al. J Am Chem Soc. 1997, 119, 8809.
  • Nodulisporic acid produces direct activation and positive allosteric modulation of AVR-14B, a glutamate-gated chloride channel from adult Brugia malayi. Choudhary S. et al. Proc Nat Acad Sci. 2022, 119.
  • Comparison of nodulisporic acid analogs in a Lucilia sericata in vitro assay and a Ctenocephalides felis membrane feeding system. Felcetto T. et al. J Parasitol. 2002, 88, 223.

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