Pidotimod is a pseudopeptide synthesised and patented by Poli Indistria Chimica, Italy in 1989 with immunostimulatory, anti-inflammatory and anti-ageing properties. Pidotimod is a fusion of L-pyroglutamate with thioproline. Pidotimod is used clinically for immunomodulation.
- A process for the preparation of 3-(L-pyroglutamate)-L-thiazolidine-4-carboxylic acid derivatives. Poli S. & DelCorona L. European Patent Organization, EP422566 A1 1991-04-17.
- Immunopharmacology of Pidotimod: effect on natural killer cell activity and thymocyte cell death. Migliorati G. et al. Pharmacol Res. 1992, 26 Suppl 2, 154.
- Effect of Pidotimod on production of pro- and anti-inflammatory cytokines ex vivo. Grigoryan S. & Ivanova A. Curr Pediat. 2011, 10, 129.