$166.00 - 1 mg
$581.00 - 5 mg
All prices in Australian dollars
- (-)-Hydrastine, (-)-β-Hydrastine, (1R,9S)-β-Hydrastine, l-Hydrastine, β-Hydrastine
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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Hydrastine, an isoquinoline alkaloid discovered in 1851, is one of the active components of the phytomedicine goldenseal (Hydrastis canadensis). Hydrastine is a mixture of four stereoisomers (two racemates). Hydrastine has convulsant, cardiac depressant, and uterine and intestinal stimulant actions. Hydrastine increases the non-adrenergic Inhibitory postsynaptic potential of smooth muscle cells of the guinea pig intestine. Recently, research has focussed on the hydrastine isomers with (-)-β-hydrastine demonstrating antiproliferative activity by inhibiting PAK4 kinase activity in human lung adenocarcinoma cells.
- A review of the pharmacology and therapeutics of Hydrastis and its alkaloids, hydrastine, berberine, and canadine. Shideman F.E. Bulletin of National Formulary Committee 1950, 18, 3.
- Effect of strychnine, hydrastine and apamin on synaptic transmission in smooth muscle cells. Vladimirova I.A. and Shuba M.F. Neirofiziologiia 1978,10, 295.
- (-)-β-hydrastine suppresses the proliferation and invasion of human lung adenocarcinoma cells by inhibiting PAK4 kinase activity. Guo B. et al. Oncol Rep. 2016, 35, 2246.