Oxostaurosporine, 7-

Oxostaurosporine, 7-

$287.00 - 1 mg

$1,005.00 - 5 mg

All prices in Australian dollars

Code
BIA-O1137
Synonyms
7-Oxostaurosporine, BMY 41950, RK 1409
CAS #
141196-69-2
Molecular Formula
C28H24N4O4
Molecular Weight
480.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Application Notes

7-Oxostaurosporine is the oxidised and highly fluorescent analogue of UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. It inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells and possesses comparable activity against tumor cells lines to UCN-01. Despite its close relationship to UCN-01 and staurosporine, limited access to the metabolite has restricted a more complete investigation of its properties.

References

  • A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I Taxonomy and biological activity. Osada, H. et al., J. Antibiot. 1992, 45, 189.
  • A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II Fermentation, Isolation, Physico-chemical properties and structure. Koshino H. et al., J. Antibiot. 1992, 45, 195.

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