Dihydropleuromutilin
Application Notes
Dihydropleuromutilin is a semi-synthetic pleuromutilin formed by selective reduction of the ethene to ethyl. Dihydropleuromutilin exhibits comparable antibiotic potency to pleuromutilin. Extensive studies have been undertaken on semi-synthetic dihydropleuromutilin analogues but the parent compound has received only limited attention.
References
- The structure and some aspects of the biosynthesis of pleuromutilin Birch A.J. et al., Tetrahedron, 1966, Suppl. 8, 359.
- New pleuromutilin derivatives with enhanced antimicrobial activity. II Structure-activity correlations. Egger H. & Reinshagen. J. Antibiot. 1976, 29, 923.