Diffractaic acid

Diffractaic acid

$150.00 - 0.50 mg

$525.00 - 2.50 mg

All prices in Australian dollars

Dirhizonic acid; NSC 5901; NSC 685595
Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Diffractaic acid is a β-orcinol depside isolated from a broad range of lichen species. Like other lichen acids, diffractaic acid has been detected as an active in a diverse range of in vitro bioassays and displays complex pharmacology as an analgesic, antipyretic, antimicrobial, plant growth inhibitor, insecticide and antitumor agent. Diffractaic acid is an important standard in the chemotaxonomy of lichens and its occurrence, use and activity are covered in over 100 entries in Scifinder up to 2016.


  • Lichen acids, plant growth inhibitors from Usnea longissima. Nishitoba Y. et al., Phytochem. 1987, 26, 3181.
  • Usnic acid and diffractaic acid as analgesic and antipyretic components of Usnea diffracta. Okuyama E. et al., Planta Med. 1995, 61, 113.
  • Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid. Kumar K.C.S. and Muller K., Europ. J. Med. Chem. 1999, 34, 405.

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