Tunicamycin complex

Tunicamycin complex

$138.00 - 5 mg

$482.00 - 25 mg

All prices in Australian dollars

Code
BIA-T1095
CAS #
11089-65-9
Molecular Formula
C38H62N4O16 (for IV)
Molecular Weight
830.4 (for IV)
Purity
>95% by HPLC (total complex)
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

The tunicamycins are a family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group. The complex comprises the analogues, tunicamycins I to X. This composition is typical of other products less precisely described as tunicamycins A to D. The tunicamycins act by blocking the formation of N-glycoside linkages to proteins via inhibition of formation of dolichol monophosphate from N-acetylglucosamine-1-phosphate. Tunicamycin blocks the synthesis of all N-linked glycoproteins (N-glycans) and causes cell cycle arrest in G1 phase. Tunicamycins are broadly active against prokaryotes, eukaryotes and viruses.

References

  • Relationship of the structure and biological activity of the natural homologues of tunicamycin. Duskin D. & Mahoney W.C. J Biol Chem. 1982, 257, 3105.

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