Tetrahydrolipstatin

Tetrahydrolipstatin

$195.00 - 25 mg

$55.00 - 5 mg

All prices in Australian dollars

Code
BIA-T1320
Synonyms
Orlipastat, Orlistat
CAS #
96829-58-2
Molecular Formula
C29H53NO5
Molecular Weight
495.7
Purity
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Application Notes

Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the treatment of obesity.

References

  • Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. Weibel E. et al., J. Antibiot. 1987, 40, 1081.
  • Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin. Barbier P. et al., Helv. Chim. Acta 1987, 70, 196.
  • The total synthesis of (−)-tetrahydrolipstatin. Bodkin J. et al., Aust. J. Chem 2003, 56, 795.

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