Teleocidin A1

Teleocidin A1

$276.00 - 1 mg

$966.00 - 5 mg

All prices in Australian dollars

Synonyms
Lyngbyatoxin, Lyngbyatoxin A, Teleocidin A 1
CAS #
70497-14-2
Molecular Formula
C27H39N3O2
Molecular Weight
437.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

Teleocidin A is a potent nematocide and acaricide produced by Streptoverticillium strains, first reported in 1960. Teleocidin A is a potent activator of protein kinase C, and also a tumor promoting agent and inducer of colony-stimulating factors. More recently, teleocidin A1 has been shown to regulate the expression of several genes. To date, the lack of availability of teleocidin has meant the truncated teleocidin-like (-)indolactam has been used to mimic teleocidin cellular responses.

References

  • A new toxic substance, teleocidin, produced by Streptomyces. Part I. Production, isolation and chemical studies. Takashima M. & Sakai H. Bull. Agr. Chem. Soc. Japan 1960, 24, 647.
  • Screening method for colony-stimulating factor inducers using a human bone marrow stromal cell line, KM-102. Kohama T. et al., J. Antibiot. 1993, 46, 1494.
  • Activity of mangosteen xanthones and teleocidin a-2 in death receptor expression enhancement and tumor necrosis factor related apoptosis-inducing ligand assays. Kikuchi H. J. Nat. Prod. 2010, 73, 452.

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