Surfactin is a complex of cyclic lipodepsipeptides produced by various strains of Bacillus subtilis, consisting of a heptapeptide cyclised with 3-hydroxy fatty acids. Surfactin was first reported in 1968 as an inhibitor of fibrin clot formation. Surfactin has broad biological activity, including as a biosurfactant, antibiotic, anti-biofilm, antifungal, antitumor and anti-inflammatory. Surfactin increases cell wall permeability, causing cell death.
- Surfactin, a crystalline peptidelipid surfactin produced by Bacillus subtilis: Isolation, characterisation and its inhibition of fibrin clot formation. Arima K. et al. Biochem. Biophys. Res. Comm. 1968, 31, 488.
- Determination of fatty acid in surfactin and elucidation of the total structure of surfactin. Kakinuma A. et al. Agr Biol Chem 1969, 33, 973.
- Biological activity of lipopeptides from Bacillus. Zhao H. et al. Review Appl Microbiol Biotechnol. 2017, 101, 5951.
- Surfactin inhibits the growth of Propionibacterium acnes by destroying the cell wall and membrane. Shan M.Y. et al. Lett Appl Microbiol. 2021, 73, 684.
- Molecular mechanism of membrane permeabilization by the peptide antibiotic surfactin. Carillo C. et al. Biochim Biophys Acta. 2003, 1611, 91.