Surfactin

Surfactin

$166.00 - 0.10 mg

$581.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-S2473
CAS #
252023-70-4
Molecular Formula
C53H93N7O13 (for C1)
Molecular Weight
1036.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Surfactin is a complex of cyclic lipodepsipeptides produced by various strains of Bacillus subtilis, consisting of a heptapeptide cyclised with 3-hydroxy fatty acids. Surfactin was first reported in 1968 as an inhibitor of fibrin clot formation. Surfactin has broad biological activity, including as a biosurfactant, antibiotic, anti-biofilm, antifungal, antitumor and anti-inflammatory. Surfactin increases cell wall permeability, causing cell death.

References

  • Surfactin, a crystalline peptidelipid surfactin produced by Bacillus subtilis: Isolation, characterisation and its inhibition of fibrin clot formation. Arima K. et al. Biochem. Biophys. Res. Comm. 1968, 31, 488.
  • Determination of fatty acid in surfactin and elucidation of the total structure of surfactin. Kakinuma A. et al. Agr Biol Chem 1969, 33, 973.
  • Biological activity of lipopeptides from Bacillus. Zhao H. et al. Review Appl Microbiol Biotechnol. 2017, 101, 5951.
  • Surfactin inhibits the growth of Propionibacterium acnes by destroying the cell wall and membrane. Shan M.Y. et al. Lett Appl Microbiol. 2021, 73, 684.
  • Molecular mechanism of membrane permeabilization by the peptide antibiotic surfactin. Carillo C. et al. Biochim Biophys Acta. 2003, 1611, 91.

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