Stephacidin B

Stephacidin B

$215.00 - 0.50 mg

$755.00 - 2.50 mg

All prices in Australian dollars

(-)-Stephacidin B
Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

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Application Notes

Stephacidin B, the dimer of avrainillamide, is a green pigment isolated from Aspergillus ochraceus and other Aspergillus sp.. Stephacidin B was reported as a potent antitumor active by Bristol Myers Squibb in 2002 against testosterone-independent PC3 and testosterone-sensitive LNCaP prostate cell lines with IC50 of 0.47 and 0.06 µM, respectively. Stephacidin is active against sensitive and resistant ovarian, colon and breast cell lines. Stephacidin B is more potent and selective than its monomeric analogue, stephacidin A. Stephacidin B is rapidly converted to avrainillamide in cell culture.


  • The natural product avrainvillamide binds to the oncoprotein nucleophosmin. Wulff J.E. et al. J Am Chem Soc .2007, 129, 14444.
  • Stephacidin A and B: Two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cells. Qian-Cutrone J. et al. J Am Chem Soc. 2002, 124, 14556.
  • Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell culture. Wulff J.E. et al. J Am Chem Soc. 2007, 129, 4898.

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