Sclerotioramine

Sclerotioramine

$189.00 - 0.50 mg

$662.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-S2942
Synonyms
Sclertiolamine, Sclerotioriamine
CAS #
1279010-29-5
Molecular Formula
C21H24ClNO4
Molecular Weight
389.88
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Sclerotioramine is an azaphilone pigment prepared synthetically from sclerotiorin and reported by Whalley and co-workers at the University of Liverpool in 1957. Subsequently, sclerotioramine was isolated as a natural product from various Penicillium species. Sclerotioramine is active against Gram positive bacteria, producing modest zones of inhibition against Staphylococcus epidermidis in a disk diffusion assay at a concentration of 30 μg/6 mm paper disk. Sclerotioramine inhibited Candida albicans, C. parapsilosis, C. tropicalis, and C. krusei (8, 7, 8, and 8 mm zones of inhibition, respectively). Sclerotioramine has moderate activity (IC50 16.31 μg/ml) in vitro against HepG2 cell line and has comparable activity to acarbose against α-glucosidase.

References

  • 986. The chemistry of fungi. Part XXVIII. Sclerotiorin and its hydrogenation products. Eade R.A. et al. J Chem Soc 1957, 4913.
  • Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an Atlantic forest soil-derived Penicillium citreonigrum. Wang X. et al. J Nat Prod 2020, 73, 942.
  • Halogenated metabolites isolated from Penicillium citreonigrum. Yuan W-H. et al. Chem Biodiversity 2014, 11, 1078.

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