L-681217
Application Notes
L-681,217 is a glycolipid-type antibiotic related to the efrotomycin class, isolated from a Streptomyces sp. L 681,217 shows broad spectrum antibiotic activity against Gram positive and Gram negative bacteria. L-681,217 inhibits bacterial protein synthesis at the elongation stage, its target being elongation factor Tu (EF-Tu).
References
- Effects of elfamycins on elongation factor Tu from Escherichia coli and Staphylococcus aureus. Hall C.C. et al., Antimicrob. Agents Chemother. 1989, 33, 322.
- L-681,217, a new and novel member of the efrotomycin family of antibiotics. Kempf A.J. et al., J. Antibiot, 1986, 39, 1361.



