Sartorypyrone A
Application Notes
Sartorypyrone A is a meroterpenoid metabolite first isolated from several species of Neosartorya in Thailand. Unlike previously reported meroterpenoids, sartorypyrone B and aszonapyrone A and B which are polycyclic, sartorypyrone A has a terminal pyrone and cyclohexane separated by a nine carbon chain. Sartorypyrone A is active against Gram negative species, E. coli, and P. aeruginosa, and Gram positive S. aureus resistant strains, and inhibits biofilm formation by S. aureus and B. subtilis.
References
- Bioactive meroditerpenes and indole alkaloids from the soil fungus Neosartorya fischeri (KUFC 6344), and the marine-derived fungi Neosartorya laciniosa (KUFC 7896) and Neosartorya tsunodae (KUFC 9213). Eamvijarn A. et al., Tetrahedron 2013, 69, 8583.
- Antibacterial and antibiofilm activities of tryptoquivalines and meroditerpenes isolated from the marine-derived fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the soil fungi N. fischeri and N. siamensis. Gomes N.M. et al., Marine Drugs 2014, 12, 822.