Sambutoxin

Sambutoxin

$200.00 - 0.50 mg

$700.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-S3085
Synonyms
(-)-Sambutoxin
CAS #
160047-56-3
Molecular Formula
C28H39NO4
Molecular Weight
453.6
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol and DMSO.

Download Data Sheets

Application Notes

Sambutoxin is a 4-hydroxy-2-pyridone fungal metabolite initially produced by Fusarium samucinum isolated from rotted potato tubers by Kim and co-workers, Seoul National University, Korea in 1995. Sambutoxin is a potent and selective inhibitor of mitochondrial respiration. Sambutoxin inhibits platelet aggregation, decreases platelet activating factor-induced disaggregation time in a dose-dependent manner and decreases thrombin and arachidonic acid-induced ATP release. Sambutoxin has remarkable antiproliferative effects, inhibiting ROS production and inducing G2/M arrest and apoptosis by activating the mitochondrial apoptosis pathway.

References

  • Kim J-C. et al. (1995). Sambutoxin: A new mycotoxin isolated from Fusarium sambucinum. Tetrahedron Lett., 36, 1047.
  • Kawai K. et al. (1997). A novel respiratory chain inhibitor, sambutoxin from Fusarium sambucinum. Cereal Res. Commun., 25, 325.
  • Hong C.M. et al. (1998). Effects of sambutoxin on the rabbit platelet aggregation. J. Toxicol. Public Health, 14, 333.

Other Products