Rugulosin – form
Application Notes
(-)-Rugulosin is the less common optical isomer of the mycotoxin, (+)-rugulosin, which was first isolated from Myrothecium verrucaria in 1968. The isomers appear not to be co-produced but both occur widely in several fungal genera. (-)-Rugulosin has been shown to be antiviral. (-)Rugulosin is the less studied of the isomers and its role as a mycotoxin is implied rather than established. There are few comparative studies of the relative potency of the isomers.
References
- Fungal metabolites. XXXII. Renewed investigation on (-)-flavoskyrin and its analogs Takeda N. et al., Tetrahedron 1973, 29, 3703.
- Further studies on the structures of luteoskyrin, rubroskyrin and rugulosin. Sankawa U. et al., Tet. Lett. 1968, 53, 5557.
- Inhibition of phage growth by an antibiotic rugulosin isolated from Myrothecium verucaria. I. Properties of the anti-phage effect. Nakamura S. et al., Jpn. J. Microbiol. 1971, 5, 113.



