Quinupristin-Dalfopristin mesylate complex

Quinupristin-Dalfopristin mesylate complex

$194.00 - 5 mg

$679.00 - 25 mg

All prices in Australian dollars

Synercid complex, Dalfopristin-Quinupristin complex
Molecular Formula
C54H71N9O13S2 (for Quinupristin mesylate); C35H54N4O12S2 (for Dalfopristin mesylate)
Molecular Weight
1118.3 (for Quinupristin mesylate) ; 786.9 (for Dalfopristin mesylate)
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Application Notes

Quinupristin-dalfopristin mesylate complex is a 70:30 (w/w) complex of two semi-synthetic analogues marketed as Synercid. Dalfopristin is a semisynthetic analogue of virginiamycin M, while quinupristin is a semi-synthetic analogue of virginiamycin B. To optimise stability, the compounds are presented as the mesylate salts with 10% sodium mesylate excess to provide a buffered aqueous solution. The complex is more hydrophobic than the naturally-occurring virginiamycin complex, with a readily ionisable group for generating a salt for improved solubility. There is little published data on the synthesis and biological activity of individual components of the complex, however the combination is a highly effective antibiotic, including activity against resistant strains.


  • Quinupristin/dalfopristin (RP 59500): A new streptogramin antibiotic. Chant C. et al., Ann. Pharm. 1995, 29, 1022.
  • Quinupristin/dalfopristin: spectrum of activity, pharmacokinetics, and initial chemical experience. Low D. Microb. Drug Resist. 1995, 1, 223.
  • Quinupristin/dalfopristin: a therapeutic review. Allington D.R. & Rivey M.P. Clin. Ther. 2001, 23, 24.

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