Quinomycin A

Quinomycin A

$120.00 - 1 mg

$420.00 - 5 mg

All prices in Australian dollars

Code
BIA-Q1102
Synonyms
Echinomycin, Actinoleukin, 1491, 59266, X 948, X 53III
CAS #
512-64-1
Molecular Formula
C51H64N12O12S2
Molecular Weight
1101.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Limited solubility in ethanol and methanol. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Quinomycin A is a cyclic depsipeptide metabolite. Quinomycin A has broad activity against bacteria, fungi and viruses, and has found application as an antitumor agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumor progression and metastasis.

References

  • Serendipitous SAD phasing of an echinomycin-(ACGTACGT)2 bisintercalation complex. Cuesta-Seijo J.A. et al., Acta Crystallogr. D Biol. Crystallogr. 2006, 62, 417.
  • Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Kong D. et al., Cancer Res. 2005, 65, 9047.
  • Echinomycin and a novel analogue induce apoptosis of HT-29 cells via the activation of MAP kinases pathway. Park J.Y. et al., Pharmacol Res. 2004, 50, 201.

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