Probetaenone I was isolated as a biosynthetic precursor of betaenone B by Oikawa and co-workers in 1988. Probetaenone I is a phytotoxic metabolite isolated from Phoma betae Fr., a causal fungus of leaf spot disease on sugar beet.
- Biosynthetic study of betaenone B: origin of the oxygen atoms and accumulation of a deoxygenated intermediate using P-450 inhibitor. Oikawa H. et al. J Chem Soc Chem Commun. 1988, 600.
- Synthesis of (–)-probetaenone I: structural confirmation of biosynthetic precursor of betaenone B. Miko S. et al. J Chem Soc Perkin Trans. 1. 1990, 1228.