Polygodial pyridazine

Polygodial pyridazine

$170.00 - 0.50 mg

$595.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-P1773
CAS #
1810726-08-9
Molecular Formula
C15H22N2
Molecular Weight
230.35
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Polygodial pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal, Antiinsectan, cytotoxic, anti-inflammatory and glucocorticoid activities.

References

  • Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis. Just J. et al., Org. Biomol. Chem. 2015, 13, 11200.
  • Effect of polygodial and its direct derivatives on the mammalian Na + /K + -ATPase activity. Garcia D.G. et al., Eur. J. Pharmacol. 2018, 831, 1.
  • Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies. Derita M. et al., Molecules 2013, 18, 2029.

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