Polygodial pyridazine
Application Notes
Polygodial pyridazine is a semi-synthetic derivative using the sesquiterpene dialdehyde, polygodial, as a scaffold. In contrast to polygodial, the pyridazine derivative is a poor inhibitor of Na+/K+-ATPase. Polygodial itself has antibiotic, antifungal, Antiinsectan, cytotoxic, anti-inflammatory and glucocorticoid activities.
References
- Practical isolation of polygodial from Tasmannia lanceolata: a viable scaffold for synthesis. Just J. et al., Org. Biomol. Chem. 2015, 13, 11200.
- Effect of polygodial and its direct derivatives on the mammalian Na + /K + -ATPase activity. Garcia D.G. et al., Eur. J. Pharmacol. 2018, 831, 1.
- Structural requirements for the antifungal activities of natural drimane sesquiterpenes and analogues, supported by conformational and electronic studies. Derita M. et al., Molecules 2013, 18, 2029.