Phenylpyropene A

Phenylpyropene A

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1815
CAS #
189564-20-3
Molecular Formula
C32H38O10
Molecular Weight
582.64
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Phenylpyropene A is a meroterpenoid isolated from Penicillium griseofulvum by researchers at the Korean Research Institute of Bioscience and Biotechnology in 2002. Phenylpyropene A inhibits conversion of cholesterol to cholesteryl esters via inhibition of acyl-CoA:cholesterol acyltransferase (ACAT). Phenylpyropene A also inhibits diacylglycerol acyltransferase (DGAT), the terminal step in triglyceride synthesis and essential for intestinal absorption and adipose tissue formation. Phenylpyropene A has significant cytotoxicity against Sf9 cells from the army worm, Spodoptera frugiperda.

References

  • Phenylpyropene A and B, new inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium griseofulvum F1959. Kwon O.E. et al., J. Antibiot. 2002, 55, 1004.
  • Inhibition of diacylglycerol acyltransferase by phenylpyropenes produced by Penicillim griseofulvum F1959. Lee S.W. et al., J. Microbiol. Biotech. 2008, 18, 1785.
  • Five new cytotoxic metabolites from the marine fungus Neosartorya pseudofischeri. Lan W.J. et al., Marine Drugs 2016, 14, 18.

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