Penicillide is a tetracycle with a central 8-membered lactone ring, produced by Penicillium, Talaromyces and other sp. first reported by Miura and co-workers, Yamagata University Japan, in 1974. Penicillide, an oxytocin inhibitor, also inhibits calpain, a calcium-activated papain-like protease with an IC50 of 7 μM becoming ineffective at 200 μM. Like its acetyl derivative, purpactin A, penicillide is a potent acyl CoA:cholesterol acyltransferase inhibitor. Penicillide is reported to be a plant growth inhibitor.
- Structure of penicillide, a new metabolite produced by a Penicillium sp. Sassa T. et al. Tetrahedron Lett. 1974, 15, 3941.
- Penicillide and derivatives as oxytocin antagonists. Pettibone D.J. and Salituro G.M. US Patent 5198463 A 1993-03-30.
- AS-186 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Penicillium asperosporum KY1635. Kuroda K. et al. J Antibiot. 1994, 47, 16.