Mitorubrin is an azaphilone isolated from the phytotoxic fungus, Penicillium rubrum. Mitorubrin is a weak antifungal and inhibitor of geranylgeranyl transferase. Mitorubrin and its derivatives were patented in Japan in 1996 as dihydrofolate reductase inhibitors for the treatment of protozoal diseases.
- The structures of mitorubrin and mitorubrinol. Buechi G et al. J Am Chem Soc. 1965, 87, 3484.
- New fungal metabolite geranylgeranyl transferase inhibitors with antifungal activity. Singh S.B. et al. Nat Prod Res. 2005, 19, 739.