Palmarumycin C3

Palmarumycin C3

$205.00 - 0.50 mg

$720.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-P1916
CAS #
159934-11-9
Molecular Formula
C20H12O6
Molecular Weight
348.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMSO, dichloromethane, acetone or methanol

Download Data Sheets

Product Data Sheet

Application Notes

The palmarumycins are fungal metabolites isolated from Coniothyrium and Sphaeropsidales sp. with antifungal, antibacterial, antitumor and herbicidal properties. Palmarumycin C3 is a yellow-green pigment which inhibits Ras farnesyl-protein transferase. Palmarumycin C3 is a more potent antimicrobial agent against A. tumefaciens, B. subtilis, P. lachrymans, R. solanacearum, S. haemolyticus, X. vesicatoria and M. oryzae than its dehydroxy analogue palmarumycin C2, with MICs in the range of 6 – 13 µg/mL. Palmarumycin C3 is a weak inhibitor of spore germination of M. oryzae and a modest antioxidant in DPPH radical scavenging and β-carotene/linoleic acid bleaching capacity assays.

References

  • Palmarumycins C1-​C16 from Coniothyrium sp.: isolation, structure elucidation, and biological activity. Krohn K. et al. Liebigs Annalen der Chemie 1994, 11, 1099.
  • Antimicrobial and antioxidant activities and effect of 1-​hexadecene addition on palmarumycin C2 and C3 yields in liquid culture of endophytic fungus Berkleasmium sp. Dzf12. Mou Y. et al. Molecul. 2013, 18, 15587.
  • Molecular pharmacology and antitumor activity of palmarumycin-​based inhibitors of thioredoxin reductase. Powis G. et al. Mol Cancer Therap. 2006, 5, 630.

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