Oligomycin A

Oligomycin A

$160.00 - 5 mg

$560.00 - 25 mg

All prices in Australian dollars

Code
BIA-O1059
CAS #
579-13-5
Molecular Formula
C45H74O11
Molecular Weight
791.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Oligomycin A is the dominant analogue of a class of macrocyclic lactones isolated from selected strains of Streptomyces sp. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.

References

  • Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N., et al., Proc. Natl Acad. Sci. U. S. A., 2006, 103, 1727.
  • Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K. K., et al., Proc. Natl Acad. Sci. U. S. A., 2001, 98, 1717.
  • The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M. E., et al., Cell Death Differ., 2000, 7, 338.

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