Neoaspergillic acid

Neoaspergillic acid

$195.00 - 0.25 mg

$685.00 - 1 mg

All prices in Australian dollars

Code
BIA-N2978
CAS #
2152-59-2
Molecular Formula
C12H20N2O2
Molecular Weight
224.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Neoaspergillic acid is a cyclic hydroxamic acid isolated in the 1960s, related to pyrazine and isolated from various Aspergillus sp.. Neoaspergillic acid shows significant inhibitory activities against some Gram positive and Gram-negative bacteria with MIC ranges of 0.5 - 16 μg/mL, and also exhibits moderate inhibitory activities against human cancer cell lines SPC-A-1, BEL-7402, SGC-7901 and K562 with IC50 ranges of 8 - 25 μg/mL.

References

  • Synthesis of neoaspergillic acid. Masaki M. et al. Tetrahedron Let. 1965, 52, 4837.
  • Biological evaluation of neoaspergillic acid, a pyrazine hydroxamic acid produced by mixed cultures of two marine-derived mangrove epiphytic fungi. Wan X. et al. Int Conf Biomed Eng Inf. 2010, 5, 1932.

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