Neoaspergillic acid is a cyclic hydroxamic acid isolated in the 1960s, related to pyrazine and isolated from various Aspergillus sp.. Neoaspergillic acid shows significant inhibitory activities against some Gram positive and Gram-negative bacteria with MIC ranges of 0.5 - 16 μg/mL, and also exhibits moderate inhibitory activities against human cancer cell lines SPC-A-1, BEL-7402, SGC-7901 and K562 with IC50 ranges of 8 - 25 μg/mL.
- Synthesis of neoaspergillic acid. Masaki M. et al. Tetrahedron Let. 1965, 52, 4837.
- Biological evaluation of neoaspergillic acid, a pyrazine hydroxamic acid produced by mixed cultures of two marine-derived mangrove epiphytic fungi. Wan X. et al. Int Conf Biomed Eng Inf. 2010, 5, 1932.