$302.00 - 0.50 mg
$1,057.00 - 2.50 mg
All prices in Australian dollars
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
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Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of thetipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines, whereas the related dedialanyl geninthiocin shows the reverse selectivity. Geninthiocin is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.
- Microbial metabolites withtipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84. Yun B-S. et al., J. Antibiot. 1994, 47, 969.
- Structural basis for antibiotic recognition by thetipA class of multidrug-resistance transcriptional regulators. Kahmann J.D. et al., EMBO J. 2003, 22, 1824.