LL Z1640-2
LL Z1640-2
$150.00 - 1 mg
$525.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-L1160
- Synonyms
- C292, L 783278, 5Z-7-Oxozeaenol
- CAS #
- 253863-19-3
- Molecular Formula
- C19H22O7
- Molecular Weight
- 362.4
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes
LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
References
- New zearalenone related macrolides and isocoumarins from an unidentified fungus. Ellestad G. A. et al., J. Org. Chem. 1978, 43, 2339.
- A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J. Ninomiya-Tsuji J. et al., J. Biol. Chem. 2003, 278, 18485.