$129.00 - 1 mg
$452.00 - 5 mg
All prices in Australian dollars
- C292, L 783278, 5Z-7-Oxozeaenol
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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LL Z1640-2 (5Z-7-oxozeaenol) is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
- New zearalenone related macrolides and isocoumarins from an unidentified fungus. Ellestad G. A. et al., J. Org. Chem. 1978, 43, 2339.
- A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J. Ninomiya-Tsuji J. et al., J. Biol. Chem. 2003, 278, 18485.