Filipin complex

Filipin complex

$245.00 - 5 mg

$858.00 - 25 mg

All prices in Australian dollars

Code
BIA-F1619
CAS #
11078-21-0
Molecular Formula
C35H58O11 (for Filipin III)
Molecular Weight
654.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Filipin complex comprises a family of pentaene macrocyclic lactones first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Filipin complex consists of four analogues, with filipin III comprising the bulk (>70%) of the complex. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.

References

  • Filipin, an antifungal antibiotic: Isolation and properties. Whitfield G.B. et al., J. Am. Chem. Soc. 1955, 77, 4799.
  • Separation of polyene antifungal antibiotics by high speed liquid chromatography. Mechlinski W. & Schaffner C.P. J. Chromatogr. 1974, 99, 619.
  • Inhibition of fungi by filipin and its antagonism by sterols. Gottlieb D. et al., Phytopathology 1960, 50, 594.

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