Embelin is benzoquinone metabolite isolated from Embelia ribes first reported in 1931. Embelin has a broad bioprofile, including antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, antidiabetic and anti-estrogenic activities. Embelin inhibits cell proliferation, induces G1 arrest and triggers apoptosis in CRPC cells, possibly via the Akt/NF-κB/survivin signaling pathway. Embelin is a privileged structure for the synthesis of antibacterial compounds.
- CCLXXXVIII.—The constitution and synthesis of embelic acid (embelin), the active principle of Embelia Ribes. Hasan K.H. & Stedman E. J Chem Soc. 1931.
- Antioxidant properties of embelin in cell culture: Electrochemistry and theoretical mechanism of scavenging. Potential scavenging of superoxide radical through the membrane cell. Caruso F. et al. Antioxidants 2020, 9, 382.
- Inhibition of Akt/NF-κB/survivin pathway by embelin on castration-resistant prostate cancer cells Xu T. et al. Int J Clin Exp Med. 2017, 10, 4386.