Elasnin

Elasnin

$225.00 - 1 mg

$790.00 - 5 mg

All prices in Australian dollars

Code
BIA-E1645
CAS #
68112-21-0
Molecular Formula
C24H40O4
Molecular Weight
392.57
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Elasnin was discovered as an inhibitor of human leukocyte elastase from Streptomyces noboritoensis by Omura and co-workers at the Kitasato Institute, Japan in 1978. Elasnin is a hydrophobic 4-hydroxypyrone with alkyl chains in the 3, 5 and 6-positions. The selective activity of elasnin for granulocyte elastase provides alternative strategies for developing new actives for the treatment of arthritis, inflammation, emphysema, and pancreatitis.

References

  • Isolation and characterization of elasnin, a new human granulocyte elastase inhibitor produced by a strain of Streptomyces. Ohno H. et al., J. Antibiot. 1978, 31, 116.
  • Structure of elasnin, a novel elastase inhibitor. Nakagawa A. et al., J. Am. Chem. Soc. 1979, 101, 4386.
  • Substituted 2-pyrones, 2-pyridones, and other congeners of elasnin as potential agents for the treatment of chronic obstructive lung diseases? Groutas W.C., J. Med. Chem. 1985, 28, 1106.

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