Diphenethylurea, N,N’-

Diphenethylurea, N,N’-

$180.00 - 1 mg

$630.00 - 5 mg

All prices in Australian dollars

Code
BIA-D2413
Synonyms
1,3-Diphenethylurea, N,N'-Bis(phenethyl)urea, NSC 25433
CAS #
5467-84-5
Molecular Formula
C17H20N2O
Molecular Weight
268.35
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

N,N’-Diphenethylurea was isolated from a marine Streptomyces by Omura and co-workers in 1978 and reported to have a weak antidepressant effect in an in vivo animal model. N,N’-Diphenethylurea, a product of phenylalanine metabolism, enhances adipocyte differentiation in 3T3-​L1 cells with expression of PPARγ2 being significantly increased in cells treated with N,​N'-​diphenethylurea compared with insulin alone.  In addition, N,​N'-​diphenethylurea-​treated cells exhibited significantly upregulated mRNA expression of adipogenic marker genes, including aP2, adiponectin and FAS during adipocyte differentiation.

References

  • 1,3-Diphenethylurea from Streptomyces sp.No.AM-2498. Iwai Y. et al. J Antibiot. 1978, 31, 375.
  • N,​N'-​diphenethylurea, a metabolite from the marine ascidian Didemnum ternatanum. Ireland C.M. J Nat Prod. 1981, 44, 360.
  • N,​N'-​diphenethylurea isolated from Okinawan ascidian Didemnum molle enhances adipocyte differentiation in 3T3-​L1 cells. Choi S-S. et al. J Antibiot. 2011, 64, 277.

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