Deferoxamine mesylate

Deferoxamine mesylate

$230.00 - 25 mg

$65.00 - 5 mg

All prices in Australian dollars

Code
BIA-D2588
Synonyms
Ba 33112, DFOM, DFX mesylate, Desferal, Desferal mesylate, Desferrioxamine B mesylate, NSC 644468
CAS #
138-14-7
Molecular Formula
C25H48N6O8.CH3SO3H
Molecular Weight
656.79
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Deferoxamine (DFO) is a siderophore isolated from Streptomyces pilosus. The mesylate salt of DFO is used clinically to treat conditions of iron overload. DFO has antibacterial, cytoprotective and antioxidant activity. DFO promotes revascularization via the activation of vascular endothelial cell function by an Akt-​eNOS-​dependent mechanism. DFO decreases beta-amyloid deposition and induces autophagy.

References

  • The antibacterial activity of a siderophore. 3. The activity of deferoxamine in vitro and its influence on the effect of antibiotics against Escherichia coli, Proteus mirabilis and coagulase-​negative staphylococci. Hartzen S.H. et al. APMIS 1994, 102, 219.
  • Deferoxamine inhibits microglial activation, attenuates blood-​brain barrier disruption, rescues dendritic damage, and improves spatial memory in a mouse model of microhemorrhages. He X-F. et al. J Neuroch. 2016, 138, 436.
  • Deferoxamine promotes angiogenesis via the activation of vascular endothelial cell function. Ikeda Y. et al. Atherosclerosis 2011, 215, 339.

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