Daunorubicin hydrochloride

Daunorubicin hydrochloride

$180.00 - 1 mg

$630.00 - 5 mg

All prices in Australian dollars

Code
BIA-D2311
Synonyms
Cerubidine, Daunoblastin, Daunomycin chlorohydrate, NDC 0082-4155, Ondena, RP 13057 hydrochloride, Rubidomycin hydrochloride
CAS #
23541-50-6
Molecular Formula
C27H29NO10.HCl
Molecular Weight
563.98
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Application Notes

Daunorubicin HCl (daunomycin HCl), an anthracycline antibiotic with potent antitumor activity, was first isolated from S. peucetius by scientists from Farmitalia. The mechanism of action of daunomycin is complex and incompletely understood. Daunomycin binds reversibly to double stranded DNA with (G.C) base specificity leading to inhibition of transcription.  Daunomycin activates signalling pathways, including a sphingomyelinase-initiated sphingomyelin-ceramide pathway, mitogen-activated kinase and stress-activated protein/c-Jun N-terminal kinase activation, transcription factors such as nuclear factor kappa B, as well as the Fas/Fas-ligand system.

References

  • ‘Daunomycin’, a new antibiotic of the rhodomycin group. Di Marco A. et al. Nature 1964, 201, 706.
  • Intercalative drug binding to DNA. Wang A.H-J. Curr Opin Struct Biol. 1992,2, 361.
  • Signaling pathways activated by daunorubicin. Laurent G. and Jaffrézou J.P. Blood 2001, 98, 913.

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