Cyclosporin H

Cyclosporin H

$145.00 - 1 mg

$510.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1248
Synonyms
5-(N-methyl-D-valine)cyclosporine A
CAS #
83602-39-5
Molecular Formula
C62H111N11O12
Molecular Weight
1202.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Cyclosporin H is a minor analogue of the cyclosporin family which is immunologically inactive as it does not bind to immunophilin. Cyclosporin H is the most extensively investigated of the minor cyclosporin analogues . It is a potent inhibitor of tumor-promoting phorbol esters on mouse skin in vivo, and of calcium/calmodulin-dependent EF-2 phosphorylation in vitro, a potent and selective antagonist of formyl peptide receptor and inhibitor of formyl peptide-induced superoxide formation.

References

  • The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Gschwendt M. et al., BBRC 1988, 150, 545.
  • Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation. Wenzel-Seifert K. et al., J. Immunol. 1991, 147, 1940.
  • Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E. Wenzel-Seifert K. & Seifert R. J. Immunol. 1993, 150, 4591.

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