Cyclosporin D

Cyclosporin D

$145.00 - 1 mg

$510.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1247
Synonyms
7-L-valinecyclosporine A
CAS #
63775-96-2
Molecular Formula
C63H113N11O12
Molecular Weight
1216.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumor-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.

References

  • The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro. Gschwendt M. et al., BBRC 1988, 150, 545.

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