Curvularin

Curvularin

$265.00 - 1 mg

$930.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1125
Synonyms
S-Curvularin, NSC 166071
CAS #
10140-70-2
Molecular Formula
C16H20O5
Molecular Weight
292.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Curvularin is a 12-membered macrocyclic lactone incorporating a resorcinyl moiety, produced by a number of fungal species including Curvularia, Penicillium and Alternaria. Curvularin exhibits a distinctly different biological profile to the structurally similar resorcylic acid lactones such as the zearalenones, radicicol and LL Z1640-2. Curvularin inhibits cell division by disrupting mitotic spindle formation and is known to be phytotoxic. More recent investigations have shown that curvularin is a highly selective transcription-based inhibitor of iNOS-dependent NO production, acting on the Janus tyrosine kinase-STAT pathway. This action offers an approach to the development of drugs inhibiting iNOS overproduction associated with NO pathophysiology.

References

  • Studies in relation to biosynthesis. Part XX. The structure and biosynthesis of curvularin. Birch J. A. et al., J. Chem. Soc. 1959, 3146.
  • Sporogen, S14-95 and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Yao Y. et al., Mol. Pharmacol. 2003, 63, 383.

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