Creatine

Creatine

$195.00 - 25 mg

$55.00 - 5 mg

All prices in Australian dollars

Code
BIA-C2637
Synonyms
N-​(aminoiminomethyl)​-​N-​methylglycine​, hydrate
CAS #
57-00-1
Molecular Formula
C4H9N3O2
Molecular Weight
131.1
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

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Application Notes

Creatine is an endogenous amino acid produced by vertebrates and occurring primarily in muscle cells as phosphocreatine. Creatine is neuroprotective in vitro enhancing survival of glutamate-​treated neuronal​/glial cells, modulating Ras​/NF-​kappaB signaling, and increases the generation of reactive oxygen species. Creatine protects against anoxia in rodent models of cerebral ischemia. Creatine has immunomodulatory activity in vitro.

References

  • Creatine enhances survival of glutamate-​treated neuronal​/glial cells, modulates Ras​/NF-​kappaB signaling, and increases the generation of reactive oxygen species. Juravleva E. et al. J Neurosci Res. 2005, 79, 224.
  • Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat. Lensman M. et al. Brain Res. 2006, 1114, 187.
  • Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase. Kilvenyi P. et al. Neurobiol Dis. 2004, 15, 610.

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