Creatine

Creatine

$195.00 - 25 mg

$55.00 - 5 mg

All prices in Australian dollars

Code
BIA-C2637
Synonyms
N-​(aminoiminomethyl)​-​N-​methylglycine​, hydrate
CAS #
57-00-1
Molecular Formula
C4H9N3O2
Molecular Weight
131.1
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Creatine is an endogenous amino acid produced by vertebrates and occurring primarily in muscle cells as phosphocreatine. Creatine is neuroprotective in vitro enhancing survival of glutamate-​treated neuronal​/glial cells, modulating Ras​/NF-​kappaB signaling, and increases the generation of reactive oxygen species. Creatine protects against anoxia in rodent models of cerebral ischemia. Creatine has immunomodulatory activity in vitro.

References

  • Creatine enhances survival of glutamate-​treated neuronal​/glial cells, modulates Ras​/NF-​kappaB signaling, and increases the generation of reactive oxygen species. Juravleva E. et al. J Neurosci Res. 2005, 79, 224.
  • Intracerebroventricular administration of creatine protects against damage by global cerebral ischemia in rat. Lensman M. et al. Brain Res. 2006, 1114, 187.
  • Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase. Kilvenyi P. et al. Neurobiol Dis. 2004, 15, 610.

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