Chloramphenicol succinate sodium
Chloramphenicol succinate sodium
$230.00 - 25 mg
$65.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-C1479
- Synonyms
- Chloramphenicol sodium succinate
- CAS #
- 982-57-0
- Molecular Formula
- C15H15Cl2N2O8Na
- Molecular Weight
- 445.2
- Purity
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.
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Application Notes
Chloramphenicol succinate sodium is the salt prepared from chloramphenicol succinate using the free carboxylic acid of the succinate which ionises and readily forms in weak sodium hydroxide solutions. The sodium salt is the preferred formulation for pharmaceutical applications, providing a more readily soluble product. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.
References
- Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehydrogenase: possible reason for its toxicity. Ambekar C.S. et al., Toxicology in Vitro 2004, 18, 441.