Chloramphenicol base

Chloramphenicol base

$230.00 - 25 mg

$65.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1475
CAS #
716-61-0
Molecular Formula
C9H12N2O4
Molecular Weight
212.2
Purity
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Chloramphenicol base is the parent 4-nitrophenylpropylamine formed by the hydrolysis of the dichloroacetamide of chloramphenicol and is a degradation product commonly encountered with commercial production of chloramphenicol. Chloramphenicol base has no antibiotic activity but has played an integral role in the synthesis and SAR of new generation antibiotics, notably thiamphenicol and experimental analogues, bromamphenicol and methamphenicol.

References

  • Chloramphenicol (chloromycetin). IV. Chemical studies. Rebstock M.C. et al., J. Am. Chem. Soc. 1949, 71, 2458.
  • Chloramphenicol (chloromycetin). VI. A synthetic approach. Long L.M. & Troutman H.D. J. Am. Chem. Soc. 1949, 71, 2469.
  • Biochemical studies on chloramphenicol. III. Isolation and identification of metabolic products in urine. Glazko A.J. et al., J. Biol. Chem. 1950, 183, 679.

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